(RTTNews) - Instil Bio (TIL), a clinical-stage biopharmaceutical company, on Tuesday announced significant clinical progress for its PD-L1xVEGF bispecific antibody, IMM2510/SYN-2510, in advanced non-small cell lung cancer or NSCLC.
The first patient has been dosed in a Phase 1b/2 clinical trial of IMM2510/SYN-2510 in combination with chemotherapy, conducted by Instil's collaborator, ImmuneOnco, in China.
The trial is targeting first-line advanced NSCLC patients, with initial clinical data expected to be available by the second half of 2025.
Instil Bio is also planning its own Phase 1 trial of IMM2510/SYN-2510 in the U.S. in the second half of 2025, pending necessary regulatory approvals.
IMM2510/SYN-2510, developed for treating multiple solid tumors, aims to enhance immune response through its VEGF trap and PD-L1 mechanism, potentially improving therapeutic outcomes in NSCLC.
Bronson Crouch, CEO of Instil Bio, said, "We are excited about the clinical progress and the potential of IMM2510/SYN-2510 in NSCLC. The data from ImmuneOnco's trial could be pivotal in advancing this therapy toward global registrational studies."
Instil Bio plans to continue advancing IMM2510/SYN-2510 in its clinical development pipeline to improve outcomes for NSCLC patients.
Currently, TIL is trading at $20.29 up by 6.68%.
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