Bill Alpert
Health
ATRA
CELG
GILD
NOVN.EB
ROG.EB
Atara Biotherapeutics
Celgene
Gilead Sciences
Roche Holding
Roche Holding AG
Juno Therapeutics
Kite Pharma
Novartis
Biotechnology
Health Care/Life Sciences
Biological Therapy
Amit Bar-On
Pascal Touchon
North America
United States
Research/Development
Corporate/Industrial News
New Product/Service Testing
Political/General News
Medical Research
Health
Medical Conditions
Multiple Sclerosis
Sciences/Humanities
Medical Treatments/Procedures
ATRA
GILD
I/BTC
M/HCR
N/CNW
N/DJN
N/GEN
N/HLT
N/RND
N/SCN
N/WER
NOVN.EB
NVS
R/NME
R/US
RHHBY
RO.EB
ROG.EB
Barrons.com
Barrons Blogs
Wires
CODES_REVIEWED
Health
author
Bill Alpert
author|Bill Alpert
topicid
8520
name
Bill Alpert
extractedtext
Bill Alpert
rank
1
codetype
author
code
bill_alpert
nameformat
surname_first
author
Bill Alpert
id
Bill Alpert
barrons_display_subject
BARHEALTH
barrons_display_subject|BARHEALTH
codetype
BARRONS_DISPLAY_SUBJECT
canbedisplaysubject
true
value
BARHEALTH
source
MANUAL
status
modified
name
Health
code
BARHEALTH
co
hofman
co|hofman
country
CH
symbol
ROG.EB
codetype
co
displayname
Roche Holding
why
occur
extractedtext
Roche Holding
source
FACTIVA
seoname
roche_holding
name
Roche Holding
relevancerange
low
chartingsymbol
STOCK/CH/XSWX/ROG
fcode
hofman
fullextractedtext
Roche Holding
ticker
RHHBY
confidence
100
subcat
com
code
hofman
relevance
25
significance
passing
onlinesignificance
passing-mention
confidencerange
high
exchangeisocode
XSWX
co
atabio
co|atabio
country
US
symbol
ATRA
codetype
co
displayname
Atara Biotherapeutics
why
about
extractedtext
Atara Biotherapeutics
source
FACTIVA
occurs
true
seoname
atara_biotherapeutics
name
Atara Biotherapeutics
orgtype
public
countrycode
US
relevancerange
high
chartingsymbol
STOCK/US/XNAS/ATRA
fcode
atabio
fullextractedtext
Atara Biotherapeutics
ticker
ATRA
confidence
100
subcat
com
code
atabio
relevance
78
significance
prominent
onlinesignificance
prominent
confidencerange
high
exchange
Nasdaq
exchangeisocode
XNAS
co
junoth
co|junoth
fullextractedtext
Juno Therapeutics
codetype
co
displayname
Juno Therapeutics
confidence
100
why
occur
extractedtext
Juno Therapeutics
source
FACTIVA
subcat
com
code
junoth
relevance
8
name
Juno Therapeutics
significance
passing
onlinesignificance
passing-mention
confidencerange
high
relevancerange
low
fcode
junoth
co
ktphi
co|ktphi
fullextractedtext
Kite Pharma
codetype
co
displayname
Kite Pharma
confidence
100
why
occur
extractedtext
Kite Pharma
source
FACTIVA
subcat
com
code
ktphi
relevance
8
name
Kite Pharma
significance
passing
onlinesignificance
passing-mention
confidencerange
high
relevancerange
low
fcode
ktphi
co
sndoz
co|sndoz
country
US
symbol
NOVN.EB
codetype
co
displayname
Novartis
why
occur
extractedtext
Novartis
source
FACTIVA
seoname
novartis
name
Novartis
countrycode
US
relevancerange
low
chartingsymbol
STOCK/US/XNYS/NVS
fcode
sndoz
fullextractedtext
Novartis
ticker
NVS
confidence
100
subcat
com
code
sndoz
relevance
7
significance
passing
onlinesignificance
passing-mention
confidencerange
high
exchange
NYSE
exchangeisocode
XNYS
co
Celgene
co|Celgene
fullextractedtext
Celgene
country
US
symbol
CELG
ticker
CELG
codetype
co
displayname
Celgene
extractedtext
Celgene
source
FACTIVA
subcat
com
code
celgene
seoname
celgene
name
Celgene
significance
passing
onlinesignificance
passing-mention
countrycode
US
exchange
Nasdaq
exchangeisocode
XNAS
chartingsymbol
STOCK/US/XNAS/CELG
status
modified
co
HOFMAN
co|HOFMAN
symbol
ROG.EB
country
CH
codetype
co
displayname
Roche Holding
metadataonly
true
source
MANUAL
code
ch_rog
name
Roche Holding AG
significance
prominent
onlinesignificance
passing-mention
exchange
Switzerland: SWX
exchangeisocode
XSWX
chartingsymbol
STOCK/CH/XSWX/ROG
fcode
HOFMAN
status
modified
co
GILSCI
co|GILSCI
symbol
GILD
country
US
codetype
co
displayname
Gilead Sciences
extractedtext
Gilead Sciences
source
MANUAL
code
gild
name
Gilead Sciences
significance
prominent
onlinesignificance
prominent
exchange
U.S.: Nasdaq
exchangeisocode
XNAS
chartingsymbol
STOCK/US/XNAS/GILD
fcode
GILSCI
status
modified
company
ATRA
company|ATRA
name
Atara Biotherapeutics
significance
PROMINENT
company
ROG.EB
company|ROG.EB
name
Roche Holding
significance
PASSING-MENTION
company
GILD
company|GILD
name
Gilead Sciences
significance
PROMINENT
company
CELG
company|CELG
name
Celgene
significance
PASSING-MENTION
company
NOVN.EB
company|NOVN.EB
name
Novartis
significance
PASSING-MENTION
djn
GILD
djn|GILD
significance
passing
onlinesignificance
passing-mention
name
GILD
why
occur
source
FACTIVA
fcode
GILD
codetype
djn
code
gild
djn
RHHBY
djn|RHHBY
codetype
djn
why
occur
source
FACTIVA
code
rhhby
name
RHHBY
significance
passing
onlinesignificance
passing-mention
fcode
RHHBY
djn
RO.EB
djn|RO.EB
codetype
djn
why
occur
source
FACTIVA
code
ro_eb
name
RO.EB
significance
passing
onlinesignificance
passing-mention
fcode
RO.EB
djn
ROG.EB
djn|ROG.EB
codetype
djn
why
occur
source
FACTIVA
code
rog_eb
name
ROG.EB
significance
passing
onlinesignificance
passing-mention
fcode
ROG.EB
djn
ATRA
djn|ATRA
codetype
djn
why
about
source
FACTIVA
occurs
true
code
atra
name
ATRA
significance
prominent
onlinesignificance
prominent
fcode
ATRA
djn
NOVN.EB
djn|NOVN.EB
codetype
djn
why
occur
source
FACTIVA
code
novn_eb
name
NOVN.EB
significance
passing
onlinesignificance
passing-mention
fcode
NOVN.EB
djn
NVS
djn|NVS
codetype
djn
why
occur
source
FACTIVA
code
nvs
name
NVS
significance
passing
onlinesignificance
passing-mention
fcode
NVS
djn
I/BTC
djn|I/BTC
codetype
djn
name
I/BTC
why
lineage
source
FACTIVA
code
i_btc
fcode
I/BTC
djn
M/HCR
djn|M/HCR
codetype
djn
name
M/HCR
why
lineage
source
FACTIVA
code
m_hcr
fcode
M/HCR
djn
N/RND
djn|N/RND
codetype
djn
name
N/RND
why
lineage
source
FACTIVA
code
n_rnd
fcode
N/RND
djn
N/CNW
djn|N/CNW
codetype
djn
name
N/CNW
why
lineage
source
FACTIVA
code
n_cnw
fcode
N/CNW
djn
N/GEN
djn|N/GEN
codetype
djn
name
N/GEN
why
lineage
source
FACTIVA
code
n_gen
fcode
N/GEN
djn
N/HLT
djn|N/HLT
codetype
djn
name
N/HLT
why
lineage
source
FACTIVA
code
n_hlt
fcode
N/HLT
djn
N/SCN
djn|N/SCN
codetype
djn
name
N/SCN
why
lineage
source
FACTIVA
code
n_scn
fcode
N/SCN
djn
R/US
djn|R/US
codetype
djn
why
about
source
FACTIVA
code
r_us
name
R/US
significance
prominent
onlinesignificance
prominent
fcode
R/US
djn
R/NME
djn|R/NME
codetype
djn
name
R/NME
why
lineage
source
FACTIVA
code
r_nme
fcode
R/NME
djn
N/DJN
djn|N/DJN
codetype
djn
name
N/DJN
source
DJN-CONTROL
code
n_djn
value
N/DJN
status
modified
inactivebydefault
true
djn
N/WER
djn|N/WER
codetype
djn
name
N/WER
source
DJN-CONTROL
code
n_wer
value
N/WER
status
modified
inactivebydefault
true
editorial-seo-id
atara-biotherapeutics-tests-multiple-sclerosis-drug-cheap-stock-51568377687
editorial-seo-id|atara-biotherapeutics-tests-multiple-sclerosis-drug-cheap-stock-51568377687
first_publish_headline
A Cheap Biotech Stock With a Novel Treatment for Multiple Sclerosis
first_publish_headline|A Cheap Biotech Stock With a Novel Treatment for Multiple Sclerosis
flow
NWREGULAR
flow|NWREGULAR
codetype
FLOW
name
Wires
source
MANUAL
value
NWREGULAR
code
NWREGULAR
status
modified
flow
Barrons.com
flow|Barrons.com
codetype
FLOW
name
Barrons.com
source
MANUAL
value
Barrons.com
code
online
status
modified
name
Online
title
Product
code
Barrons.com
flow
Barrons Blogs
flow|Barrons Blogs
codetype
FLOW
source
MANUAL
title
Product
code
Barrons_Blogs
name
Barrons Blogs
value
Barrons Blogs
status
modified
headline
A Cheap Biotech Stock With a Novel Treatment for Multiple Sclerosis
headline|A Cheap Biotech Stock With a Novel Treatment for Multiple Sclerosis
in
i2569
in|i2569
codetype
in
name
Biotechnology
why
lineage
source
FACTIVA
code
i2569
fcode
i2569
in
i951
in|i951
codetype
in
name
Health Care/Life Sciences
why
lineage
source
FACTIVA
code
i951
fcode
i951
in
ibiother
in|ibiother
codetype
in
name
Biological Therapy
why
association
source
FACTIVA
code
ibiother
fcode
ibiother
media
media-2
media|media-2
responsive
layout
wrap
softcrop
Horizontal
imphotoid
im-106515
location
https://images.barrons.com/im-106515/?size=1.5
media
media-1
media|media-1
softcrop
Horizontal
imphotoid
im-106515
location
https://images.barrons.com/im-106515/?size=1.5
ns
gmltps
ns|gmltps
codetype
ns
why
about
source
FACTIVA
code
gmltps
name
Multiple Sclerosis
significance
prominent
onlinesignificance
prominent
fcode
gmltps
ns
ctrial
ns|ctrial
codetype
ns
why
about
source
FACTIVA
code
ctrial
name
New Product/Service Testing
significance
prominent
onlinesignificance
prominent
fcode
ctrial
ns
gcrese
ns|gcrese
codetype
ns
why
about
source
FACTIVA
code
gcrese
name
Medical Research
significance
prominent
onlinesignificance
prominent
fcode
gcrese
ns
gtrea
ns|gtrea
codetype
ns
why
about
source
FACTIVA
code
gtrea
name
Medical Treatments/Procedures
significance
prominent
onlinesignificance
prominent
fcode
gtrea
ns
c23
ns|c23
codetype
ns
name
Research/Development
why
lineage
source
FACTIVA
code
c23
fcode
c23
ns
ccat
ns|ccat
codetype
ns
name
Corporate/Industrial News
why
lineage
source
FACTIVA
code
ccat
fcode
ccat
ns
gcat
ns|gcat
codetype
ns
name
Political/General News
why
lineage
source
FACTIVA
code
gcat
fcode
gcat
ns
ghea
ns|ghea
codetype
ns
name
Health
why
lineage
source
FACTIVA
code
ghea
fcode
ghea
ns
gmed
ns|gmed
codetype
ns
name
Medical Conditions
why
lineage
source
FACTIVA
code
gmed
fcode
gmed
ns
gsci
ns|gsci
codetype
ns
name
Sciences/Humanities
why
lineage
source
FACTIVA
code
gsci
fcode
gsci
nwchain
SB527738632899569448639045855461503520820861
nwchain|SB527738632899569448639045855461503520820861
pe
Amit Bar-On
pe|Amit Bar-On
lastname
Bar-On
codetype
pe
displayname
Bar-On, Amit
extractedtext
Amit Bar-On
source
FACTIVA
code
amit_bar_on
name
Amit Bar-On
firstname
Amit
nameformat
surname_first
pe
Pascal Touchon
pe|Pascal Touchon
lastname
Touchon
codetype
pe
displayname
Touchon, Pascal
extractedtext
Pascal Touchon
source
FACTIVA
code
pascal_touchon
name
Pascal Touchon
firstname
Pascal
nameformat
surname_first
re
usa
re|usa
codetype
re
why
about
source
FACTIVA
subcat
cntry
code
usa
name
United States
significance
prominent
onlinesignificance
prominent
fcode
usa
re
namz
re|namz
codetype
re
why
lineage
source
FACTIVA
subcat
snr
code
namz
name
North America
fcode
namz
relay
SYND
relay|SYND
codetype
RELAY
name
Syndication
source
EXPANDER
value
SYND
code
synd
status
modified
statistic
CODES_REVIEWED
statistic|CODES_REVIEWED
name
CODES_REVIEWED
value
CODES_REVIEWED
codetype
STATISTIC
code
CODES_REVIEWED
subject
BARHEALTH
subject|BARHEALTH
ruleid
BARHEALTH
codetype
SUBJECT
value
BARHEALTH
canbedisplaysubject
true
name
Health
title
Health
status
modified
code
BARHEALTH
wordcount
851
wordcount|851
Photograph by Marcelo Leal
A Cheap Biotech Stock With a Novel Treatment for Multiple Sclerosis
A Cheap Biotech Stock With a Novel Treatment for Multiple Sclerosis
A Cheap Biotech Stock Tests a Novel Treatment for Multiple Sclerosis
Researchers reported that Atara’ Biotherapeutics treatment showed hints of actually improving the condition of MS patients, instead of just slowing the disease like most available treatments.
A Cheap Biotech Is Testing a Novel Treatment for Multiple Sclerosis
Researchers reported that Atara Biotherapeutics treatment showed hints of actually improving the condition of MS patients, instead of just slowing the disease like most available treatments.
https://www.barrons.com/articles/j-k-rowling-donates-18-9-million-to-ms-research-01568318421
https://www.barrons.com/articles/biogen-stock-multiple-sclerosis-drug-51561726837
mailto:william.alpert@barrons.com
A Cheap Biotech Stock With a Novel Treatment for Multiple Sclerosis
By Bill Alpert
Photograph by Marcelo Leal
Atara Biotherapeutics has an out-of-favor stock and a novel treatment for multiple sclerosis that’s in early clinical trials. At an international meeting of MS doctors on Friday, researchers reported that Atara’s therapy showed hints of actually improving the condition of MS patients, instead of just slowing the disease like most available treatments.
If subsequent trials over the next few years confirm the treatment’s effectiveness, Atara could enter the market for MS drugs. That market approached $20 billion last year, so the opportunity will be significant, for a company of Atara’s size.
The South San Francisco-based firm (ticker: ATRA) had a $50 stock and $3 billion market capitalization last year. Today, its stock trades below $16 and its market cap is just $870 million. That is why investors may want to pay attention to the progress of the MS treatment that Atara currently calls ATA188.
Friday afternoon, at the annual meeting of the European Committee for Treatment and Research in Multiple Sclerosis, in Stockholm, a group of doctors led by University of Pennsylvania researcher Amit Bar-On will present results on the first dozen patients treated with Atara’s therapy. The Phase 1 study was primarily designed to test safety, but it also measured the treatment’s effect on the patients’ symptoms.
The patients all have a severe form of multiple sclerosis called “progressive,” in which their condition continuously declines—instead of the sometimes remitting, then relapsing, form that is most common. There are few treatments available for the progressive forms of the disease.
An abstract of the ATA188 study says the Atara MS treatment was safe and well-tolerated. More intriguing were the efficacy signals. Symptoms in a number of the patients stabilized or improved as those people received increasing doses.
“Recently approved drugs just slow the progression,” Atara chief executive Pascal Touchon told Barron’s, “so if we can stabilize the patients or even improve them, this will be a significant treatment.”
Researchers will follow up this first study with a randomized, controlled, double-blind trial to test efficacy. That could take a couple of years, with another year for analysis, says Touchon.
The need for MS treatments is large. The U.S. has a million people living with the disease. Worldwide, there are more than twice that number. Recently-approved MS treatments have therefore been some of the most successful biotech launches. The Ocrevus product from Roche Holding (RHHBY) hit $2.4 billion in sales in 2018, its second year on the market.
Atara’s treatment is the first that targets a recently suspected cause of multiple sclerosis: the Epstein-Barr virus. The virus is what gives people mononucleosis. MS sufferers typically had mono at an early age and the virus is present in the immune system B-cells of every MS patient. A bunch of genetic traits and immune malfunctions contribute to the nerve scarring that afflicts MS patients, but virus-infected B-cells seem to be a key part.
The ATA188 treatment modifies another actor of the immune system known as the T-cell, to target Epstein-Barr infected B-cells. The reason that Atara stock sold for 50 bucks last year is that Wall Street was ga-ga over these so-called CAR-T therapies, after a few of them showed dramatic success against blood cancers such as lymphoma and leukemia.
In 2017, Gilead Sciences (GILD) paid $12 billion for Kite Pharma and its now-approved treatment for lymphoma, called Yescarta. Celgene (CELG) bought Juno Therapeutics for $9 billion in 2018. Novartis (NVS) has an approved CAR-T treatment for leukemia, Kymriah, that sells for $475,000.
But sales of the approved CAR-T treatments have been slow to grow. That disappointment helped make Atara a cheaper stock—along with the company’s acknowledgment this year that recruitment was going slowly for the clinical trial of its first experimental T-cell treatment, known as tab-cel, which targets a rare form of leukemia caused by the Epstein-Barr virus in some transplant patients.
Atara’s ATA188 MS treatment differs from other CAR-T technologies in an interesting way. Most CAR-T therapies extract the patient’s own T-cells and then soup them up in an expensive and time-consuming process. The ATA188 treatment uses off-the-shelf T-cells from healthy donors, making it cheaper and more convenient.
Atara has already built a $50 million manufacturing facility for its off-the-shelf treatment. A recent stock offering should fund operations until 2021, said Touchon.
With a promising treatment under investigation by the world’s leading multiple-sclerosis researchers, and several other T-cell products in the pipeline, Atara and its beaten-up stock deserve a second look.
Write to Bill Alpert at william.alpert@barrons.com
The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.