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908 Devices Inc. (NASDAQ: MASS)
Q4 2021 Earnings Call
Mar 07, 2022, 4:30 p.m. ET
Contents:
- Prepared Remarks
- Questions and Answers
- Call Participants
Prepared Remarks:
Operator
Good day, and thank you for standing by. Welcome to the 908 Devices fourth quarter 2021 financial results conference call. [Operator instructions] Please be advised, this call is being recorded. [Operator instructions] I would now like to hand the conference over to your host today, Kelly Gura.
Please go ahead.
Kelly Gura -- Investor Relations
Thank you. This afternoon, 908 Devices released financial results for the quarter and full year ended December 31, 2021. If you've not received this news release or if you'd like to be added to the company's distribution list, please send an email to ir@908devices.com. Joining me today from 908 is Kevin Knopp, chief executive officer and co-founder; and Joe Griffith, chief financial officer.
Before we begin, I'd like to remind you that management will make statements during this call that are forward-looking statements within the meaning of federal securities laws. These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated. Additional information regarding these risks and uncertainties appears in the section entitled Forward-Looking Statements in the press release 908 Devices issued today. For a more complete list and description, please see the risk factors section of the company's annual report on Form 10-K for the year ended December 31, 2021, and in its other filings with the Securities and Exchange Commission.
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Except as required by law, 908 Devices disclaims any intention or obligation to update or revise any financial projections or forward-looking statements, whether because of new information, future events or otherwise. This conference call contains time-sensitive information and is accurate only as of the live broadcast, March 7, 2022. With that, I would like to turn the call over to Kevin.
Kevin Knopp -- Chief Executive Officer and Co-Founder
Thanks, Kelly. Good morning, and thank you for joining our fourth quarter 2021earnings call I could not be more pleased with the positive trajectory of our business as we closed out 2021. We ended the fourth quarter with $15.8 million in revenue, bringing our total revenue for 2021 to $42.2 million, up 57% from the prior year.
These results are a testament to the strength of our organization, and I thank our employees for their efforts. Before I provide more detail on our fourth quarter and full year results, I'd like to take this opportunity to welcome Tony Hunt, president and CEO of Repligen, to our board of directors. Tony has a wealth of knowledge and experience in bioproduction, and his perspective will be an important addition to our board as we broaden our bioanalytics platform. Throughout 2021, we made meaningful progress on the growth objectives we set forth at the start of the year.
These objectives included scaling our commercial team, demonstrating traction within our growing customer base and expanding the capabilities of our existing products and the reach of our technology platform within our core forensics, research and biopharma applications. Starting with our sales channels and commercial organization, we continue to add top talent throughout the fourth quarter, and we now have reached our goal of 60 commercial employees, doubling from a year ago. As of year-end, we have employees in 12 countries, and our handheld and desktop devices are available across six continents in more than 40 countries. We have also expanded our distribution channels to further our global reach.
Moving on to customer traction, adoption for existing and new customers across all product lines was strong throughout the year. In the fourth quarter, we added 221 devices and 45 new customers, bringing our installed base to 1,935 devices. With our handheld, we significantly progressed enterprisewide adoption of our MX908 with leading agencies, including the Department of Homeland Security, the Drug Enforcement Administration, the Department of Agriculture and U.S. Defense Forces.
The growing opioid crisis continues to be a major driver of customer adoption. According to the CDC, there was an estimated 100,000 drug overdose deaths in the U.S. between May 2020 and April 2021, a staggering 30% increase from the prior year. The CDC also reported that synthetic opioids, mainly fentanyl, were involved in 64% of these overdoses.
This is evident in the State of Ohio, which has been one of the highest rates of drug overdose deaths involving opioids. To combat this crisis, the Ohio Attorney General's Office has deployed multiple MX908 Devices within its Bureau of Criminal Investigation. In October, they implemented a pilot program for police departments in three cities where law enforcement officers are using the MX908 for rapid mobile drug testing. The AG's office considers the MX to be a game-changer and successes continue to be reported in the news.
Recently, BCI agents use the MX908 after a suspect had broke open a bag of suspicious substance, and minutes later, agents determine legal fentanyl was included in the mixture. This is a great example of how high-fidelity chemical detection at the point of need can really make an impact in critical-to-life applications. Our goal is for our handheld mass spec to become the standard bearer for global chemical response, and we are making strong progress toward this objective. This includes our partnering with leading trading organizations, including Guardian Center of Georgia and the LSU National Center for Biomedical Research and Training, which, collectively, trained thousands of first responders worldwide each year on the best modern tactics.
Turning now to our desktops, we've reached our goal of placing our desktop devices into all 20 of the top 20 pharmaceutical companies. Since the launch of Rebel in November of 2019, we have sold 100 units. Notably, nearly 40% of these devices went to the top 20 pharmaceutical companies, and 15 customers have already purchased multiple Rebel units. As we've previously shared, there's a growing need to measure multiple product critical quality attributes, or CQAs, and to monitor and control the underlying process in order to improve yield and predictability in biotherapeutics.
Our desktop devices are well-positioned to meet these needs. Last year, Amgen and GSK published papers on the use of ZipChip to measure multiple critical quality attributes simultaneously. These papers noted efficiency gains, including increased throughput by 20 times from 200 minutes down to just 10 minutes, with comparable results to conventional LCMS methods. The process in forming power of the Rebel analyte panel was demonstrated by Johns Hopkins University researchers in a paper published in biotechnology and bioengineering in November.
Researchers developed a model to facilitate process control mammalian cells, providing a cost-effective method to control nutrient growth and limit undesirable metabolomic byproducts. Our Rebel device facilitated development and validation of the model through enabling at-line analysis. The Rebel's process in forming power was also demonstrated by Sartorius scientists in their in-silico predictive modeling work, which presented at our first integrated user meeting focused on bioprocess monitoring, counterfeit pharmaceuticals and high-throughput drug screening in proteomics. Moving to the expansion of our technology platform, during the year, we continued to unlock our platform's capabilities by increasing areas of use for customers in opening addressable markets.
To accomplish this, we released analyte panel extensions, new software applications, assay kits, accessory modules and third-party hardware and software integrations. For our back handheld device, we released an aerosol module accessory to detect and identify aerosolized chemical hazards and a Bluetooth capability that enables seamless data transfer and accelerate support in the field. We also added 19 new analyte targets, mainly synthetic drug compounds such as cannabinoid, cathinone and opioids. For our desktops, we partnered with Sartorius to integrate our Rebel and Lightstream into their SIMCA data exploratory tool to allow customers to garner deeper actionable insights.
We released a new assay kit for our ZipChip device that provides a simple, rapid and cost-effective method for oligonucleotide analysis. Recently, Protegene, a leading European CRO within Protein Sciences, noted that our ZipChip Oligos kit provided substantial value for their customers compared with conventional approaches. They said the new workflow gives them the possibility to analyze new sample types without the need of harsh eye-impairing agents, and it requires only a small amount of sample, something they already appreciate with all their other ZipChip kits. While we're largely focused on bioanalytics as the primary application for our desktops, there's a breadth of opportunity for our products and technologies beyond bioanalytics, including proteomics and metabolomics.
At the Annual Conference of the American Society for Mass Spectrometry, or ASMS, we presented developments in these areas. We updated the scientific community on our microfluidic chip technology advances, highlighting a tenfold improvement in sensitivity, allowing us to capture and measure lower-abundance proteins. Also at ASMS, scientists from Dana-Farber Cancer Institute presented their results using our prototype microfluidic chips, which showed a significant time savings, 20 minutes versus 90 minutes with traditional chromatography methods. Importantly, the opportunity for our products is large and rapidly growing.
Today, we estimate that the total addressable market for our products is approximately $5 billion across forensics, research and bioprocessing, reaching customers in pharma, biotech, government and academia. We have shared that over the coming years, we expect the opportunity to grow to $22 billion for our handhelds and desktops, as we extend the QA/QC and expand our desktop capabilities in research and bioprocess with the emergence of advanced therapies. We see the biopharmaceutical industry is, indeed, nearing an inflection point with the increasing pipeline of advanced therapeutics and the critical need for analytics to enable more real-time control for process efficiency and predictability. I want to share a few industry metrics that really underscore this.
First, as of Q3 2021, the Alliance for Regenerative Medicine estimates that there are more than 2,200 ongoing clinical trials of regenerative medicine, including cell and gene therapies. Second, the FDA is experiencing significant growth in cell and gene therapy field with original investigational new drug applications growing from approximately 148 in 2006 to approximately 300 in 2021. And finally, this past January, at the Advanced Therapies Suite Conference, the FDA stated that they expected approximately 10 to 20 new advanced therapy approvals per year through 2025. Given these industry trends, we continue to expect our total addressable market to expand significantly over time, as these advanced therapies take hold in the market.
Compared to traditional monoclonal antibodies, advanced therapies require a multifold increase in the number of measurements due to the smaller production batches given the personalized nature of these therapies. Our desktop devices are well-positioned to meet this growing need for analytics. Our Rebel device automates the outline monitoring of process attributes and enables the streaming of 32 analytes critical to cell function and productivity prediction. Our ZipChip device enables the rapid characterization of multiple quality attributes simultaneously, 20 times faster than conventional LC with little to no method development.
We're already making significant progress in penetrating this opportunity with the Rebel device. As of year-end, nearly one in every four Rebel placements was for cell and gene therapy applications, double that from a year ago. We also have several significant research collaborations with more than a third of these partnerships, specifically focused on cell and gene therapies. And we are confident this is only the beginning.
We continue to believe we have a strong value proposition to offer the biopharma industry as well as other markets. Looking forward to 2022, we are focused on five key areas to drive long-term growth. First, expanding our installed base and increasing utilization within accounts; second, accelerating commercialization; third, developing and advancing our existing products; fourth, broadening our bioanalytics platform; and fifth, laying the Omics Foundation to address emerging opportunities. Starting with our first objective surrounding customer adoption, for our handhelds, we're building a strong foundation of testing, trials and pilots that we have the potential to evolve into valuable enterprise accounts.
As of year-end, we now have more than 10 pilot programs of approximately 100 units, more than double one year ago. We also progressed to 12 enterprise accounts and maintained significant ongoing potential of 700-plus units across those accounts despite shipping approximately 300 units to these accounts over the last year. We continue to see significant pipeline opportunity for our handhelds and work closely with our customers to identify budget and funding to drive enterprise adoption. For our desktops, we are employing a penetrate and radiate strategy.
We are working to penetrate new accounts and, importantly, radiate across the large number of biopharma accounts where we now have a foothold. Our sales opportunity pipeline continues to grow and, at year-end, is 50% higher than that of a year ago. Turning to our second objective, accelerating commercialization. We are harnessing the investments from 2021 and plan to further expand our commercial team to 80 by the end of the year.
This will position us to continue ramping up our international efforts and geographic investment. We have demonstrated progress with the addition of employees across our key regions, and we expect to build upon this by deepening our footprint in these locations over the course of the year. Turning to our third objective, developing and advancing our product portfolio. Today, we have a robust product portfolio, and we are continuing to build upon the capabilities of the existing products, as well as expand the reach of our technology platform.
In 2022, we will continue to unlock our platform's capability to increase the areas of use for our customers and further penetrate our addressable market. These new capabilities include the consistent releases of additional analytes assay, accessories and data integrations across our handheld and desktop devices over the course of the year. Furthermore, this includes efforts with customers and partners to advance data utilization and process understanding leading to progressively higher pull-throughs on Rebel over time, which is meaningful today at approximately 40% for active users. At our core, we are a technology-driven company with a broad and differentiated platform for organic growth.
Going forward, we anticipate major product releases on a cadence of every 24 to 36 months with the aim of expanding device capabilities and new generations of products and capitalizing on replacement cycles. Turning to our fourth objective, broadening our bioanalytics platform. We are creating a comprehensive bioanalytic platform for biotherapeutic development through production. Our goal is to become an enabler of biopharma 4.0 with a tech stack of connected process monitoring and critical product quality attribute analysis devices that informs models that support better real-time predictive outcomes.
With increasingly advanced therapies, the industry necessitates automated solutions to drive biomanufacturing quality, efficiency and cost improvements to achieve production of the desired product manufacturers' need to identify and understand critical process parameters and their impact on critical quality product attributes during process development in the entire biomanufacturing workflow. The need for simple, automated analyzer devices for measuring and monitoring process and product attributes has never been greater. Specialized scientific and engineering personnel are in high demand and workloads are expanding in proportion to growing drug pipeline. And finally, our fifth objective, laying an Omics Foundation with the rise of proteomics 2.0 and the broader desire for an understanding of how proteins orchestrate a cell's function.
There's significant interest in determining protein abundances, which proteins are present; localization, where they are; and activities, what they're doing, within and around cell. With this interest and demand, we see an emerging need for accelerating mass spec-based workflows to address proteomics and metabolomics opportunities. Mas spec Omics workflows are bottlenecked by sample preparation and high-performance separation. The latter, in particular, can take hours with conventional chromatography.
Our electronically driven chip technology has the potential to reduce sample preparation requirements and accelerate the separation step from hours to minutes. To that end, Dr. Will Thompson, principal scientist at 908 Devices, presented a poster and lightning talk just last week at the U.S. HUPO Conference in Charleston, showcasing serum measurements with attomolar sensitivity using high-resolution separations that could be completed in just minutes.
We expect the continued cadence of technology research and publications with KOLs and partners to support future product launches and workflows in the Omics domain. We have shown tangible results across these areas throughout 2021, and we are well-positioned for continued growth in 2022. I'm confident we've laid a solid foundation and built a strong team that will enable us to execute on these initiatives. We are better positioned than ever to capitalize on the opportunity ahead and continue toward our goal of democratizing laboratory mass spectrometry and bringing it to the point of need.
I'll now turn the call over to Joe who will provide more detail on our financials and discuss our outlook for 2022.
Joe Griffith -- Chief Financial Officer
Thanks, Kevin. Revenue for the fourth quarter of 2021 was $15.8 million, compared to $12.5 million in the third quarter and $5.7 million in the prior-year period. Total revenue for the full year 2021 was $42.2 million, up 57% from $26.9 million in 2020. Product and service revenue for the fourth quarter 2021 was $15.6 million, compared to $5.9 million in the prior-year period, representing growth of 163%.
The increase was primarily driven by our handheld devices where we shipped 140 more devices in the fourth quarter of 2021 compared to the prior-year period. Total product and service revenue for the full year 2021 was $41.1 million, up 66% from $24.8 million in 2020. Handheld revenue from our MX908 product for the fourth quarter 2021 was $11.3 million, an increase of $8.2 million, compared to $3.1 million in the prior-year period. The increase was primarily driven by our pacing of shipments to the U.S.
Army. For the full year 2021, we have recognized approximately 50% of the revenue from the existing purchase commitments in place with the U.S. Army. Throughout 2021, we added to the initial opportunity and further see additional potential in our enterprise account pipeline.
Desktop revenue from our Rebel and ZipChip products for the fourth quarter 2021 was $4.3 million, compared to $2.8 million in the prior-year period, representing growth of 53%. This was primarily due to an increase in device placements, five each for Rebel and ZipChip, as well as an increase in recurring revenues. Recurring revenues, consisting of consumables, accessories and service revenue, for the fourth quarter 2021 was $2.4 million, compared to $1.4 million in the prior-year period, representing growth of 73%. The increase was primarily driven by service revenue, as well as an increase in consumable revenue related to Rebel kit sales.
License and contract revenue for the fourth quarter 2021 was approximately $300,000 and $1.1 million for the full year of 2021, down 49% over the full year 2020. As previously stated, we do not expect our license and contract revenues to be a significant contributor of revenue on a go-forward basis. Our installed base grew to 1,935 units with 221 devices shipped during the fourth quarter. We shipped 191 MX908 handheld devices, 20 Rebel desktop devices and 10 ZipChip interface desktop devices during the quarter.
Gross profit was $9.1 million for the fourth quarter of 2021, compared to $2.6 million for the prior-year period. The increased gross profit of $6.6 million was primarily driven by a $6.1 million increase in product and service gross profit resulting from higher device sales across our products. Gross margin was 58% for the fourth quarter 2021 as compared to 45% for the prior-year period. Gross margin was 55% for the full year 2021, in line with the prior-year period.
Total operating expenses for the fourth quarter of 2021 were $12.7 million, compared to $6.5 million in the prior-year period. The increase was driven primarily by headcount expansion across our business, as well as expenses related to marketing activities, consulting and travel. Net loss for the fourth quarter of 2021 was $3.5 million, compared to $10.2 million in the prior-year period. Net loss for the full year 2021 was $22.2 million, compared to $12.9 million in the prior-year period.
We ended the fourth quarter of 2021 with approximately $224 million in cash and cash equivalent. This includes approximately $94 million of net proceeds from our follow-on offering completed in November 2021. In addition, we had $15 million of debt outstanding. We are well-capitalized to execute on our current strategic priorities.
At 908, we have always had a culture of disciplined capital allocation. In 2022, we will continue to prioritize our operational expenditures to achieve our long-term growth objectives. Looking ahead for 2022, we expect revenue to be in the range of $52 million to $55 million, representing growth of 23% to 30% over full year 2021. This range contemplates some remaining macro uncertainties of COVID-19, supply chain constraints, and the delay of the full year 2022 U.S.
federal government budget as operational risks. Even with this lingering impact, we believe we are well-positioned to achieve our stated objectives and deliver strong growth for 2022. This year, we expect seasonality to be consistent with prior years, reflecting the impacts of the U.S. government year-end purchasing cycle of September 30 and typical year-end pharma and biotech spending in the fourth quarter.
As a result, we expect revenue for 2022 to be similar to our cadence of 2021 with approximately two-thirds of revenue to be recognized in the second half of the year. At this point, I would like to turn the call back to Kevin for closing comments.
Kevin Knopp -- Chief Executive Officer and Co-Founder
Thanks, Joe. We ended the year strong as we steadily executed on our commercial strategy while providing value to our customers through our mass spec devices. I'm confident that the foundation we have laid for 2022 will support our long-term sustainable growth. We are just scratching the surface of what is possible with our technology, and we look forward to updating you on our progress across our different focus areas throughout the year.
With that, we'll now open it up for questions.
Questions & Answers:
Operator
And thank you. [Operator instructions] And our first question comes from Brian Weinstein from Blair. Your line is now open.
Dustin Scaringe -- William Blair -- Analyst
Hey, guys, this is Dustin, on for Brian. In relation to what's going on in the macro environment right now and all the uncertainty, we're kind of wondering what you guys are seeing from customers right now. What's the appetite on bringing new technologies? And what's the overall awareness of your product, especially on the desktop side?
Kevin Knopp -- Chief Executive Officer and Co-Founder
Yeah, hi, Dustin, this is Kevin. Yeah, I think we're -- today, we're really addressing what we think is critical to life applications. So as you know, we're really working to accelerate biotherapeutic development, and then, we're also working to make a dent and impact in the opioid crisis. So we have continued to see throughout the last really 24 months that we've considered to see customers keeping our technology a priority because they have these real and measurable impacts on those important.
Dustin Scaringe -- William Blair -- Analyst
Great. Thank you. And then, I know you gave some color on the U.S. Army contract, so about 50% was realized.
But how should we think that falls through through the rest of 2020?
Joe Griffith -- Chief Financial Officer
Sure. Absolutely, Dustin. So on the -- due to competitive dynamics, as well as some of our customer sensitivities, we won't be disclosing the exact amounts as you're probably aware. But the U.S.
Army is baked into our 2022 guidance and the visibility that we have into this revenue. Their adoption of large enterprise customers really gives us that full enterprise customers confidence as others come into play. We're excited to be partnered with the U.S. Army and continue to see shipments.
We have them in Q3, Q4, and fulfill the rest of the devices over the first nine months of 2022. We feel we've made progress with enterprise accounts, which are forecasted to grow in 2022 and are contemplated our guidance. But happy to address any other questions that you have. But super excited by that opportunity.
Dustin Scaringe -- William Blair -- Analyst
Sure. And lastly, maybe just wondering what you're seeing on the broader sales cycle. Is that improving over time as you're making the incremental commercial investments in your sales team? I know you mentioned bringing that up this year, but just wondering how that is tracking.
Kevin Knopp -- Chief Executive Officer and Co-Founder
Yeah, I mean, we are expecting the investments to be made in sales and marketing in 2021 to help drive growth here in 2022. And they're contributing in maybe three different ways, I would say, the funnel progression with the marketing team, increasing the lead gen, and then driving the application support for the pre and post sales, which is so important to get customers and driving the referrals. And then, direct reps have been out prospecting in these new territories and expanding territories. So to many of our reps, our new reps are really focused on the desktop area, as we see as a big priority for us.
So we expect our desktop revenues to have good growth overall for 2022 and as they come up, that productivity curve. So by midyear, yeah, we really expect these reps to be pretty productive, and that's going to help get us to our goals here in the back half.
Dustin Scaringe -- William Blair -- Analyst
Great. Thank you.
Operator
And thank you. And our next question comes from Puneet Souda from SVB Leerink. Your line is now open.
Puneet Souda -- SVB Leerink -- Analyst
Yeah, hi, Kevin, Joe, thanks for taking the questions. So first one, on the guide, it appears you're bracketing the Street number and essentially in line with that. But as we look at the business, you had 20 Rebel placements, which was ahead of us. You have solid momentum with the Army orders and MX908.
I mean, Rebel has been on the market for two years and getting into cell and gene therapy, and now you're expanding your sales force, which, correct me if I'm wrong, it expanded from six to 60, and now, you're expanding it to 80 on the commercial side. So with all that momentum, maybe could you just talk to us about sort of what is driving you to be having some conservatism in the guide for the full year?
Kevin Knopp -- Chief Executive Officer and Co-Founder
Absolutely. As we think about the guide and the opportunity there, we set our initial guidance based upon the knowledge at this time and considering certain market factors and expectations on our investments that we made, as you highlighted here in 2021. With those investment activities as we move into the first half, we believe we're laying that strong foundation for growth for 2022 and beyond. So as we think about that range and some of the levers and the opportunities, I think, on the maybe downside is on COVID may not enable some of the international activities to open up until maybe late Q2 into H2, which could limit growth opportunities for both our handhelds and our desktops.
The U.S., if they don't pass a budget, we're forced to live within the continuing resolutions where we are today. If not resolved by early Q2, this could put pressure on our ability to realize some of the handheld sales within the guide from our existing and new accounts. We do see upside with our handled customers, if we're able to secure funding and progress more rapidly through those pilots and the adoption of our technology across a broader user base. And also, if we're successful in our ability to radiate and penetrate Rebel, as you mentioned, we had a strong Q4 on those Rebel customer counts, expand our installed base and our drive higher active utilization among our installed base, so pretty balanced approach.
Puneet Souda -- SVB Leerink -- Analyst
Got it. OK. No, that's fair. And then, Kevin, it's great to see Tony Hunt on the board.
As you look at the bioprocessing capabilities that you have, the Rebel capabilities, I think you highlighted a couple of points. I just want to make sure. I mean, what are the priorities for that platform this year and expansion in terms of maybe the analytes and overall features and capabilities that you would want to add? Obviously, it's great to see the progress that you're doing in cell and gene therapy accounts.
Joe Griffith -- Chief Financial Officer
Yeah. Thank you. Yeah, we really -- as previously mentioned in the script there, we really do see that the biopharma industry nearing that inflection point and just really demanding these analytics like we can provide with our desktops, Rebel, and ZipChip. And the pipeline, as you said there, on the advanced therapeutics that we've been getting some traction in, really drives that critical need and to enable more of the real-time control, if you will, for process efficiency and predictability.
So I think we're quite pleased with our progress there. I think, as you look forward into 2022, there's two real areas. One is that what we'd like to coin is that penetrate and radiate where we got to those top 20, but we're really just seeding the beginning of an account that we believe can have significant capacity within. And so we're working to radiate across that.
And then in parallel, really working as we build those placements to continue our recurring revenue, our consumable stream there. So one of the priorities that you're going to see and continue to see here is on the consumable pull-through related to their utilization in terms of measurements that we call it that informing power on the Rebel, and we highlighted that we had work with John Hopkins with their beautiful paper out there that showed that the analyte power of what Rebel provides is very informing of their next steps of these predictive models. And Sartorius as well showcased in silico model that, again, analytes that like the Rebel provides are very informative. So you're going to see us prioritizing continuing the placement of new boxes into those accounts and radiating across that and then continuing to work on the utilization.
Puneet Souda -- SVB Leerink -- Analyst
OK. Super. And then, just last one for me. In terms of the proteomics, thanks for the update there.
When should we expect that new product to reach the market? Thank you.
Kevin Knopp -- Chief Executive Officer and Co-Founder
Yeah, we're very excited about the proteomics work. Today, it is an R&D project, and we really do commit to keeping the scientific community updated. And as you know, we created a great SAB panel with some wonderful proteomics leaders that are helping advise us, and we did just have a very nice talk with some really game-changing performance last week down at the HUPO. So -- but today, it really remains an R&D project.
It is based on our ZipChip platform, as you know, adding a soft base extraction bed to that. So if you look forward to it through 2022, we don't have a -- we consider it an R&D project, and we don't have a contribution for this work in our guidance for 2022. So it will take some time, but stay tuned, and we'll keep everybody abreast through the community of scientific progress.
Puneet Souda -- SVB Leerink -- Analyst
OK. Great. Thanks, guys. Good to see the progress.
Thanks.
Kevin Knopp -- Chief Executive Officer and Co-Founder
Thanks, Puneet.
Operator
Thank you. And our next question comes from Dan Arias from Stifel. Your line is now open.
Dan Arias -- Stifel Financial Corp. -- Analyst
Afternoon, guys. Thanks for the questions. Kevin or maybe Joe, can you just expand on the comments on Rebel usage and maybe talk to pull-through for 2022? I mean, I know that calculation gets impacted by the new users that come in and as a denominator, and they come in at low contributors. But if you just sort of look at the existing customers, and Kevin to your idea, of expanding utilization as one of your goals, what kind of growth do you think you might see among those that have Rebels today and are up and using them?
Joe Griffith -- Chief Financial Officer
Just maybe I'll start off, Dan, and then Kevin can chime in, too. Yeah, we have seen some broad range of customer use cases over the last year and really two years since we started. We have some customers that are more in the two to three, but a lot just getting out of the gate. And we are seeing more -- as customers utilize the device more and more, they get more comfortable and take more measurements.
So today, the active users at approximately that one kit a month, we see that likely continuing in 2022 and how we've looked at it within our guidance range that we've put out there. We are focused on driving higher utilization and are seeing paths for that and seeing some customers start to consider purchasing multiple units, largely for convenience. So increasing utilization within accounts but lowering the run rate with each -- within each unit, so I think you were touching on. So as far as accelerating ruble pull-through, there are multiple factors we feel in play, including the ramp time, as I alluded to, and the focus on placements in -- and here in 2022.
I think we'll have a lot of focus on additional placements getting out there to build that installed base, and that will affect the overall average of 10 a month for those users.
Dan Arias -- Stifel Financial Corp. -- Analyst
OK. Helpful. And then, Kevin, can I just maybe ask about your expectation today versus where they were initially when you guys went public? I mean, the IPO took place, basically, mid-COVID, so obviously, you found yourselves in an operating position that was different at that time than it was a year earlier. As we enter 2022 here, how do you feel about the commercial team relative to those initial expectations just in terms of infrastructure, the ability to reach customers geographically? You mentioned hires.
I'm just curious how that's going to play out just from a global perspective. And then just overall, I'm trying to recalibrate where we are just on the selling side just as we approach what is hopefully going to be a more accommodative environment.
Kevin Knopp -- Chief Executive Officer and Co-Founder
Yeah, yeah. I think, in general, if you look back to the IPO point in December of 2020, I mean, we feel really good about the progress that we've had since that date, and we've got some real products out there, and they're really changing the paradigm of chemical and biochemical detection. And customers want to need this analysis, and they can't really wait on a supercomputer in all cases, and they need these laptops and tablets, and we see that alternately as a pretty large opportunity. We did just hit our 10-year anniversary last month, and I think we've come quite far and a lot to do.
From a commercial team side, yeah, we had about 30 people on the commercial side at the time of the IPO, and we just passed the 60, and we'll keep investing over this year to around 80 for the year. I think we've had a great progress. I don't think we see ourselves on short of opportunity. It is a massive addressable market there that's really in front of us, and we've got a highly differentiated technology product to get after it.
I do see that the world is opening up a little bit more. Obviously, as Joe mentioned, there's always a concern that a new variant comes by. And for us, that probably is more impactful on the international side of our business. But historically, that's been a small percent, and we're really looking at it as an opportunity to grow.
So yeah, hope that gives you some color.
Dan Arias -- Stifel Financial Corp. -- Analyst
It does. And I could just sort of finish the thought there. What percentage of normal would you say you are right now in terms of reaching global customers? So someone in London wants you to come over and demo machine or just talk to them. How much of a capability at this point, given where we are with COVID, do you have?
Kevin Knopp -- Chief Executive Officer and Co-Founder
Yeah, I -- so obviously, we're more U.S.-centric, but we do have employees now in 12 different countries. As you know, our commercial leader for our life science, all our desktops is based out of the U.K. So that particular example, we've really been growing up teams across the U.K. and Europe.
I think, we're getting stronger by the day there to reach customers in Boston. We're calling you. We find you without any mask. They just lifted the mask mandate here in Boston, so all employees are at the office without.
So I think that's all continuing to open up. I'd say Asia is probably a more challenging area across APAC, really more limited, especially as a small team. So traveling from one country to another into APAC region is challenging, and that's probably the last thing to open up.
Joe Griffith -- Chief Financial Officer
And as far as percent of normal, we're probably at the higher percent maybe specific as you look at our business, we're greater than 80% or North America-based revenues. Yeah, we do see our business a bit more insulated than others maybe in our space. And we grew at a healthy rate during the pandemic and believe these critical to life devices have remained a priority for our customers. So I don't know if I can put a specific percent on it, but it's probably greater than 80% to 90% in our case.
Dan Arias -- Stifel Financial Corp. -- Analyst
OK. Helpful, guys. Thank you.
Operator
And Thank you. And our next question comes from Max Masucci from Cowen. Your line is now open.
Max Masucci -- Cowen and Company -- Analyst
Hi, Kevin and Joe, congrats on that nice finish to the year, and happy 10 years at 908, Kevin. Yes, so we attended the Advanced Therapeutic. I think, leaving that conference, we admittedly were a bit shocked at how clearcut the demand was for at-line analyzers. But the awareness of the available solutions that exist in the market was still somewhat challenged.
So any time you have a disruptive technology, it requires a solid outbound strategy. So would just be curious for Rebel. With the sales force that's doubled over the past year, if you had to break out how you are, number one, ability to drive new customer wins; and number two, ability to drive existing customer growth has changed with the expanded sales force, that'd be great.
Kevin Knopp -- Chief Executive Officer and Co-Founder
Yeah, yeah, that conference was straight down the fairway. The results that you and others have published out of there and certainly, the needs that were discussed at that conference are very much aligned to the needs that we're driving to serve with our bioanalytics platform across Rebel and ZipChip. You're right, it's more than just on the Street and prospect. You definitely have to raise the bullhorn a little bit, right, and we're a small company, and we're trying to do so.
So as we talk about the 30 that became 60, there's a fraction of those that are on the marketing side. And that's across product management, the outbound marketing side, everyone responsible for all stages of the funnel from the demand generation through the marketing qualified leads and inside sales. They're also quite efficient in getting the word out. And we've also been really ramping up over last year just the number of things we're doing with external parties and key opinion leaders, and we'll continue to do that in 2022.
So I think there is a thirst for new analyzers. I think there is a demand for new insights as you look at these advanced therapies. And the analytics, we really view as key and are going to keep working to make sure we're heard.
Max Masucci -- Cowen and Company -- Analyst
That's great. And just a follow-up here, and then I'll save my questions for our discussion tomorrow. But my assumption is that the messaging of the sales force for 2022 is we're going to continue to prioritize placements, just given a lot of these opportunities are -- they're advancing, but still nascent. But I would just be curious to hear how you are targeting consumable sales, like if you have Rebel-focused reps that are driving both placements and consumables or if you're splitting up those duties.
Kevin Knopp -- Chief Executive Officer and Co-Founder
Yeah, great question. And I think about and tied to your last question, too, the growth and the execution on our sales channel. On the desktop side, we are expecting growth to approach approximately two times the growth rate overall. That's really where a lot of excitement and opportunity is.
And part of it is with the sales team, not only go after the devices but the consumables. And we have a handful of inside sales, but we do have our sales team in their bag, both the upfront device as well as the consumables. So their quotas include both. And we think that's important to keep them tied to the customer and the customer relationship as they buy, hopefully, that second and even more devices and buying in that upfront commitment on whether it's initial six months of consumables or kits or coming back at renewal to get additional as they ramp up their utilization rate.
So we do keep it all in one bag, supplemented by inside sales.
Max Masucci -- Cowen and Company -- Analyst
Great. I appreciate the color, and talk to you tomorrow.
Kevin Knopp -- Chief Executive Officer and Co-Founder
All right. Thanks, Max.
Operator
Thank you. And I am showing no further questions. I would now like to turn the call back over to Kevin Knopp for closing remarks.
Kevin Knopp -- Chief Executive Officer and Co-Founder
Yeah, thank you very much. Thanks, everyone, for joining our call this afternoon, and look forward to seeing some of you at the Cowen conference this week. And have a great day.
Operator
This concludes today's conference call. Thank you for participating. You may now disconnect.
Duration: 45 minutes
Call participants:
Kelly Gura -- Investor Relations
Kevin Knopp -- Chief Executive Officer and Co-Founder
Joe Griffith -- Chief Financial Officer
Dustin Scaringe -- William Blair -- Analyst
Puneet Souda -- SVB Leerink -- Analyst
Dan Arias -- Stifel Financial Corp. -- Analyst
Max Masucci -- Cowen and Company -- Analyst
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