Credit: Shutterstock photoAdamas Pharmaceuticals, Inc.ADMS announced positive data from the phase III study - EASE LID 3 - on its lead wholly owned candidate, ADS-5102 extended-release capsules, for the treatment of levodopa-induced dyskinesia (LID) associated with Parkinson's disease (PD). We expect investors to react positively to the news.
Data from the study demonstrated a statistically significant reduction in LID at 12 weeks in patients receiving ADS-5102, compared with placebo, as assessed by the Unified Dyskinesia Rating Scale (UDysRS). The candidate was safe and generally well tolerated. The study met its primary endpoint. Results were presented at the World Parkinson Congress in Portland.
In addition, Adamas Pharma announced positive post-hoc analysis of data from the EASE LID study on ADS-5102. Results from the study showed an improvement in activities of daily living (ADLs) in PD patients.
The company is presently conducting an open-label safety study - EASE LID 2 - which is open to patients from EASED, EASE LID and EASE LID 3, and LID patients who have undergone deep brain stimulation. Patients in the study will be followed for up to two years.
Meanwhile, Adamas Pharma expects to file a New Drug Application (NDA) for ADS-5102 for the treatment of LID later this year.
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PD, a chronic progressive motor disorder, is said to impact 800,000 individuals in the U.S. Out of this, motor complications affect about 400,000 patients, and LID occurs in about 150,000 patients.
Successful development and commercialization of ADS-5102 will enable the company to capture a large share of the market, which currently has no approved drug in the indication.
Note that ADS-5102 is also being evaluated in a phase II study for the treatment of symptoms associated with multiple sclerosis in patients with walking impairment.
Going ahead, we expect investor focus to remain on further pipeline updates by the company.
Adamas Pharma currently carries a Zacks Rank #4 (Sell). Some better-ranked stocks in the health care sector include Pacira Pharmaceuticals, Inc. PCRX , Corcept Therapeutics Incorporated CORT and ANI Pharmaceuticals, Inc. ANIP . All three stocks sport a Zacks Rank #1 (Strong Buy). You can see the complete list of today's Zacks #1 Rank stocks here .
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The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.
The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.
